After treatment of hypertension, which hormonal levels will be altered in a patient treated with lisinopril and hydrochlorothiazide?

When a patient is treated with lisinopril, an ACE inhibitor, it affects the renin-angiotensin system by inhibiting the conversion of angiotensin I to angiotensin II. As a result, while angiotensin II levels decrease, the levels of angiotensin I can actually rise because the feedback mechanism that would normally convert angiotensin I to angiotensin II is disrupted.

In the context of hydrochlorothiazide, a thiazide diuretic, it also promotes sodium excretion and can lead to a compensatory increase in renin release from the kidneys, which further contributes to elevated angiotensin I levels. However, the increase in renin and subsequent angiotensin I typically does not change due to the direct modulation of the angiotensin-converting enzyme activity by lisinopril. Therefore, in terms of direct hormonal changes after the administration of lisinopril and hydrochlorothiazide, there would effectively be no significant change in angiotensin I levels.

This is why it is correct to state that there will be no change in angiotensin I levels after treatment with these medications.