What is the most likely viral cause of a newborn presenting with jaundice, hepatomegaly, and intracranial calcifications?

The most likely viral cause of a newborn presenting with jaundice, hepatomegaly, and intracranial calcifications is Cytomegalovirus (CMV). CMV is a member of the herpesvirus family and is one of the most common congenital infections. When a baby is infected with CMV during pregnancy, it can lead to a range of symptoms including jaundice and hepatomegaly due to liver involvement, as well as neurological consequences such as intracranial calcifications, which typically occur due to the virus affecting the developing brain.

The presence of these symptoms aligns well with congenital CMV infection, often leading to a classic presentation of microcephaly, developmental delays, and sensory impairments in addition to the acute symptoms observed at birth. The combination of jaundice, hepatomegaly, and the distinctive finding of intracranial calcifications in newborns strongly indicates CMV as the causative agent in this scenario.